• The Gill Lab

  • Gold nanoparticles
    Gold nanoparticles as a novel
    platform for development and
    delivery of influenza vaccines.
    (Image Credit: Wenqian Tao)
  • Confocal image of pollens
    Plant pollens and spores as
    a novel platform for oral
    delivery of vaccines.
    (Image Credit: Yunzhe Ma)
  • Microneedle array
    Painless microneedles for
    vaccine and drug delivery to various
    tissues of the human body.
    (Image Credit: Harvinder Gill)
  • SEM of pollens
    Plant pollens and spores as
    a novel platform for oral
    delivery of vaccines.
    (Image Credit: Jasim Uddin)
  • Oral cavity histology
    Microneedles for local delivery
    of cancer medications to
    oral cavity for management of
    oro-pharyngeal tumors.
    (Image Credit: Yunzhe Ma)


  1. AK Shakya, CH Lee, and HS Gill, “Cutaneous vaccination with coated microneedles prevents development of airway allergy”, Journal of Controlled Release, 2017 Aug 15. pii: S0168-3659(17)30779-4. doi: 10.1016/j.jconrel.2017.08.012. PMID: 28821461
  2. CG Macedo, AK Jain, M Franz-Montan, MH Napimoga, JT Clemente-Napimoga, and HS Gill, “Microneedles enhance topical delivery of 15-deoxy-Δ12,14-prostaglandin J2 and reduce nociception in temporomandibular joint of rats”, Journal of Controlled Release, 2017 Jul 1. pii: S0168-3659(17)30695-8. doi: 10.1016/j.jconrel.2017.06.031. PMID: 28673836
  3. W Tao, B Hurst, M Hernandez-Sanabria, R Arya, L Bimler, S Paust, EB Tarbet, and HS Gill, “Consensus M2e peptide conjugated to gold nanoparticles confers protection against H1N1, H3N2 and H5N1 influenza A viruses”, Antiviral Research, 2017, 141:p. 62–72. PMID: 28161578
  4. AK Jain, CH Lee, and HS Gill, "5-Aminolevulinic acid coated microneedles for photodynamic therapy of skin tumors", Journal of Controlled Release, 2016, http://dx.doi.org/10.1016/j.jconrel.2016.08.015. PMID: 27543445
  5. L Serpe, A Jain, CG de Macedo, MC Volpato, FC Groppo, HS Gill*, and M Franz-Montan*, "Influence of salivary washout on drug delivery to the oral cavity using coated microneedles: An in vitro evaluation", European Journal of Pharmaceutical Sciences, 2016, 93:p. 215-223. PMID: 27523787
  6. AK Shakya, MYE Chowdhury, W Tao, and HS Gill, "Mucosal vaccine delivery: Current state and a pediatric perspective", Journal of Controlled Release, http://dx.doi.org/10.1016/j.jconrel.2016.02.014. PMID: 26860287
  7. AK Shakya and HS Gill, "A comparative study of microneedle-based cutaneous immunization with other conventional routes to assess feasibility of microneedles for allergy immunotherapy", Vaccine, 2015, 33(33): p. 4060–4064. PMID: 26092307
  8. W Tao and HS Gill, "M2e-immobilized gold nanoparticles as influenza A vaccine: role of soluble M2e and longevity of protection ", Vaccine, 2015, 33(20):p. 2307-15. PMID: 25842219
  9. Y Ma†, S Boese†, Zhen Luo, N Nitin and HS Gill, "Drug coated microneedles for minimally-invasive treatment of oral carcinomas: development and in vitro evaluation", Biomedical Microdevices, 2015, 17(2):44. PMID: 25787934. †: co-first authors.
  10. Y Ma and HS Gill, "Coating solid dispersions on microneedles via a molten dip coating method: development and in vitro evaluation for transdermal delivery of a water insoluble drug", Journal of Pharmaceutical Sciences, 2014, 103(11): p. 3621-30. PMID: 25213295
  11. SA Atwe, Y Ma, and HS Gill, "Pollen grains for oral vaccination", Journal of Controlled Release, 2014, 194: p. 45-52. PMID: 25151980
  12. Y Ma, W Tao, SJ Krebs, WF Sutton, NL Haigwood, and HS Gill, "Vaccine delivery to the oral cavity using coated microneedles induces systemic and mucosal immunity", Pharmaceutical Research, 2014, 31(9): p. 2393-403. PMID: 24623480
  13. RS Ingrole, W Tao, JN Tripathy, and HS Gill, "Synthesis and immunogenicity assessment of elastin-like polypeptide-M2e fusion protein as an influenza antigen", Nano LIFE, 2014, 4 (2): p. 1450004. PMID: 25825595
  14. HS Gill, S-M Kang, F-S Quan, and RW Compans, "Cutaneous immunization – an evolving paradigm in influenza vaccines", Expert Opinion on Drug Delivery, 2014, Apr. 11(4): p. 615-27. PMID: 24521050
  15. W Tao, KS Ziemer, and HS Gill, "Gold nanoparticle-M2e conjugate co-formulated with CpG induces protective immunity against influenza A virus." Nanomedicine (Lond), 2014, 9 (2): p. 237-251. PMID: 23829488
  16. BZ Wang, HS Gill, C He, C Ou, L Wang, YC Wang, H Feng, H Zhang, MR Prausnitz, and RW Compans, "Microneedle delivery of an M2e-TLR5 ligand fusion protein to skin confers broadly cross-protective influenza immunity", Journal of Controlled Release, 2014, 178 (28): p. 1-7. PMID: 24417966
  17. Z Luo, T Ye, Y Ma, HS Gill, and N Nitin, "Micro precision delivery of oligonucleotides in a 3D tissue model and its characterization using optical imaging." Molecular Pharmaceutics, 2013, 10 (8): p. 2868–2879. PMID: 23795670
  18. BZ Wang, HS Gill, SM Kang, L Wang, YC Wang, EV Vassilieva, and RW Compans, "Enhanced influenza virus-like particle vaccines containing the extracellular domain of matrix protein 2 and a toll-like receptor ligand." Clinical and Vaccine Immunology, 2012, 19(8): p. 1119-1125. PMID: 22647270
  19. J Gupta, HS Gill, SN Andrews, and MR Prausnitz, "Kinetics of skin resealing after insertion of microneedles in human subjects." Journal of Controlled Release, 2011, 154(2): p. 148-155. PMID: 21640148
  20. S Paust, HS Gill, B-Z Wang, MP Flynn, EA Moseman, B Senman, M Szczepanik, A Telenti, PW Askenase, RW Compans, and UH von Andrian , "Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses." Nature Immunology, 2010, 11(12): p. 1127-1135. PMID: 20972432
  21. SL Banks, RR Pinninti, HS Gill, KS Paudel, PA Crooks, NK Brogden, MR Prausnitz, and AL Stinchcomb, "Transdermal delivery of naltrexol and skin permeability lifetime after microneedle treatment in hairless guinea pigs in vivo." Journal of Pharmaceutical Sciences, 2010, 99(7): p. 3072-3080. PMID: 20166200
  22. HS Gill, J Söderholm, MR Prausnitz, and M Sällberg, "Cutaneous vaccination using microneedles coated with hepatitis C DNA vaccine." Gene Therapy, 2010, 17(6): p. 811-814. PMID: 20200562
  23. S-O Choi, YC Kim, J-H Park, J Hutcheson, HS Gill, Y-K Yoon, MR Prausnitz, and MG Allen, "An electrically active microneedle array for electroporation." Biomedical Microdevices. 2010, 12(2): p. 263-273. PMID: 20012696
  24. HS Gill, S Andrews, S Sakthivel, A Fedanov, I Williams, D Garber, F Priddy, S Yellin, M Feinberg, S Staprans, and MR Prausnitz, "Selective removal of stratum corneum by microdermabrasion as a novel method of transdermal drug delivery." European Journal of Pharmaceuticals. 2009, 38(2): p. 95-103. PMID: 19559791
  25. Q Zhu, VG Zarnitsyn, L Ye, Z Wen, Y Gao, L Pan, I Skountzou, HS Gill, MR Prausnitz, C Yang, and RW Compans, "Immunization by vaccine-coated microneedle arrays protects against lethal influenza virus challenge." Proceedings of the National Academy of Sciences (PNAS). 2009, 106(19): p. 7968-7973. PMID: 19416832
  26. SL Banks, RR Pinninti, HS Gill, PA Crooks, MR Prausnitz, and AL Stinchcomb, "Flux across microneedle-treated skin is increased by increasing charge of naltrexone and naltrexol in vitro." Pharmaceutical Research, 2008, 25(7): p. 1677-1685. PMID: 18449628
  27. HS Gill, D Denson, B Burris, and MR Prausnitz, "Effect of microneedle design on pain in human subjects." Clinical Journal of Pain, 2008, 24(7): p. 585-594. PMID: 18716497
  28. DP Wermeling, SL Banks, DA Hudson, HS Gill, J Gupta, MR Prausnitz, and AL Stinchcomb. "Microneedles permit transdermal delivery of a skin-impermeant medication to humans." Proceedings of the National Academy of Sciences (PNAS), 2008, 105(6): p. 2058-2063. PMID: 18250310
  29. HS Gill and MR Prausnitz. "Pocketed microneedles for drug delivery to the skin." Journal of Physics and Chemistry of Solids, 2008, 69(5-6): p. 1537-1541. PMID: 20648232
  30. J Jiang, HS Gill, D Ghate, BE McCarey, SR Patel, HF Edelhauser, and MR Prausnitz, "Coated microneedles for drug delivery to the eye." Investigative Ophthalmology and Visual Science, 2007, 48(9): p. 4038-4043. PMID: 17724185
  31. HS Gill and MR Prausnitz, "Does needle size matter?" Journal of Diabetes Science and Technology, 2007, 1(5): p.725-729. PMID: 19885141
  32. HS Gill and MR Prausnitz, "Coating formulations for microneedles." Pharmaceutical Research, 2007, 24(7): p.1369-1380. PMID: 17385011
  33. HS Gill and MR Prausnitz, "Coated microneedles for transdermal delivery." Journal of Controlled Release, 2007, 117(2): p. 227-237. PMID: 17169459
  34. W Martanto, SP Davis, NR Holiday, J Wang, HS Gill, and MR Prausnitz, "Transdermal delivery of insulin using microneedles in vivo." Pharmaceutical Research, 2004, 21(6): p. 947-952. PMID: 15212158

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